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You'll want to unlock all your grenades mainly so you can carry more for when you level them. I wouldn't assign skill points to anything that will make the grenades do more damage. (They already do a lot of damage so rep can be fairly low). That includes other weapon skills like barrage and shrapnel in cannon that can impact grenades.
Grenades have really good passive skills, but I would be careful when assigning points to demolition, you don't want to make the area too large. Might wake up some enemies you don't want to wake up lol I like determination. I really don't know how well ignore pain or toughness works.
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