Ahoy mates! I know there has been other potion guides scattered around the forums, but I thought I should post this one since there's a video on exactly how to make this beautiful tower.
So basically what you're trying to do is make, well, a tower! You can play around with it to suit higher levels of different potions if you'd like, but this specific format works wonderfully for all the Lively Bucko Brew potions. This is what your tower should look like before you actually use your last crab claw:
Sorry for the low quality of this! But I'll probably be making another video soon with much better quality.
After you have your tower set up, drop your last blue piece right in the middle and VIOLA! An easily completed potion. This will probably take a few tries to perfect, and I even have some trouble with it sometimes, but you'll get a hang of it. Good luck, mates! And get to leveling those potions!!